Beilstein J. Org. Chem.2011,7, 404–409, doi:10.3762/bjoc.7.52
carbonylative [2 + 2 + 1] cycloaddition of allenenes was developed to prepare bicyclo[4.3.0]nonenones possessing a methyl group at the ring junction, which is difficult to achieve by the Pauson–Khand reaction of the corresponding enynes. This method also provided a new procedure for the construction of the
tricyclo[6.4.0.01,5]dodecenone framework in a satisfactory yield.
Keywords: allene; bicyclo[4.3.0] derivatives; carbonylative [2 + 2 + 1] cycloaddition; quaternary center construction; rhodium; Introduction
The Co2(CO)8-mediated Pauson–Khand reaction (PKR) [1][2] is well recognized as a formal [2 + 2 + 1
methyl group, and for the construction of the tricyclo[6.4.0.01,5]dodecenone skeleton.
Results and Discussion
In previous studies, we investigated the carbonylative [2 + 2 + 1] cycloaddition reaction of two allenenes 1 and 4 with either a SO2Ph or CO2Me substituent on the proximal double bond of the
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Graphical Abstract
Scheme 1:
Rh(I)-catalyzed Pauson–Khand type reaction of 1 and 4.